MPL15297. Mass of sodium fluoride _____ mg (1) (c)€€€€€The concentration of sodium fluoride in a prescription toothpaste is 2800 ppm. To view the changes to a medicine you must sign up and log in. Sodium fluoride applied topically after tooth eruption reduces caries by inhibiting demineralisation and promoting remineralisation of the tooth surface. 75ml. In order to prevent the accumulation of fluoride, the total fluoride intake must be assessed before this fluoride toothpaste is used. After oral administration of sodium fluoride to mice, rates and rabbits, reproductive and foeto–toxic effects were observed only at high dose levels. This product is a toothpaste in which the active ingredient is sodium fluoride present at a level of 0.619 % w/w, which corresponds to 280 mg fluoride per 100 g toothpaste. The toxic dose, i.e the lowest dose at which symptoms of intoxication can be induced, is 5 mg fluoride per Kg body weight. 3 1600 x : 23 q 2 Spy Mass of sodium fluoride [1 mark] mg The concentration of sodium fluoride in a prescription toothpaste is 2800 ppm. Start typing to retrieve search suggestions. Morningside 2800 Toothpaste contains 2800ppm of Sodium fluoride, around double the amount found in normal over the counter toothpaste. Smooth, white coloured paste with the odour and taste of spearmint. Polyethylene/copolymer/aluminium/copolymer/polyethylene laminated tube with a polypropylene flip top closure. It is a generic version of the original Colgate Duraphat toothpaste. In extremely rare cases it can prove fatal. No interaction studies have been performed. Sodium Fluoride 5000 ppm Toothpaste. Fluoride toothpaste for children. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. This product contains propylene glycol. For the full list of excipients, see section 6.1. The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. Colgate® Duraphat® 2800ppm fluoride toothpaste is suitable for adults and children over 10 years of age who may be at risk from tooth decay including patients with: This product requires no special storage conditions. Prevention and treatment of dental caries (coronal and root) adolescents and children aged ten years or more. High Fluoride Toothpastes are used to help prevent tooth decay (dental caries) and enamel erosion in patients aged 16 years and older. Dosage and administration: Use daily instead of normal … Profession specific information. Today, billions of people around the world rely on fluorid… To bookmark a medicine you must sign up and log in. Prior to the 1950s, toothpaste didn't hold much promise for oral health. This is within the acceptable limits for the amount to be supplied at one time for safety purposes. After years of research, government officials began implementing the idea of using fluoride to improve dental health. Adolescents and children aged 10 years or more: To be used daily instead of the normal toothpaste. Amazon's Choice for "duraphat 2800 ppm fluoride toothpaste" REGENERATE™ Advanced Toothpaste – Clinically proven - remineralize tooth enamel for strong, healthy teeth 75ml. This product also contains Sorbitol solution. Brushing your teeth thoroughly with fluoride toothpaste is one of the most effective ways of preventing tooth decay. In 1956, Proctor Gamble released the first fluoride-fortified toothpaste to hit the American market. 1-4 Sodium Fluoride 5000 ppm Dry Mouth brand of 1.1% sodium fluoride toothpaste in a squeeze tube is easily applied onto a toothbrush. Fluoride 2800 ppm FluorideTtoothpaste has a local, topical action on the teeth and so the route taken within the body does not apply. For … Clinical studies show that 2800ppm fluoride toothpaste delivers greater caries reduction than regular fluoride toothpaste. This information is intended for use by health professionals. Indications: For the prevention and treatment of dental caries (coronal and root) in adults and children 10 years of age and over. Bone fluorosis (osteosclerosis) will only be seen where there is high chronic absorption of fluoride (over 8 mg daily). Duraphat ® 2800 ppm Fluoride Toothpaste is a white coloured toothpaste. Pharmacotherapeutic group: caries prophylactic agents. It is well established that 1.1% sodium fluoride is safe and extraordinarily effective as a caries preventive when applied frequently with mouthpiece applicators. It is well established that 1.1% sodium fluoride is safe and extraordinarily effective as a caries preventive when applied frequently with mouthpiece applicators. To email a medicine you must sign up and log in. Peal concentrations are achieved within 30 – 60 minutes. Continue. Morningside Fluoride 2800 Toothpaste is suitable for adults and adolescents aged 16 years and over. It is effective on both enamel and exposed dentine. To bookmark a medicine you must sign up and log in. COLGATE® DURAPHAT® 2800PPM FLUORIDE TOOTHPASTE IS A PRESCRIPTION-ONLY HIGH-FLUORIDE TOOTHPASTE. In contrast, toothpastes containing over 5,000 ppm of fluoride ion, or 1.1 % sodium fluoride, are available only as prescription products provided by registered dental professionals. A pea-sized amount of toothpaste is approximately one-quarter of an inch. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Epidemiological studies in humans indicate that fluoride has no adverse effects in pregnancy or on the health of the foetus or new born child. Avoid drinking or rinsing mouth for 30 minutes after use. A 5000 ppm high fluoride toothpaste reduces the cavity risk even more, estimated to be about a 42% reduction. Instructions for use: Date of first authorisation/renewal of the authorisation. Colgate® Duraphat® 2800ppm fluoride toothpaste is a high fluoride toothpaste for use twice a day, one being last thing at night for protection against tooth decay. High fluoride toothpaste. It allows continued monitoring of the benefit/risk balance of the medicinal product. Commercially available fluoride toothpastes for general sale in New Zealand have differing levels of fluoride content ranging from approximately 500 parts per million (ppm) to 1,450 ppm fluoride. Each 1 g of toothpaste contains 2.8 mg fluoride (as sodium fluoride), which is 2800 ppm fluoride. High Fluoride Toothpaste is used to help prevent tooth decay (dental caries) and enamel erosion in patients aged 16 years and older. But all toothpastes, even prescription ones, will contain other ingredients that target oral health problems such as bad breath, tartar build up and sensitivity. 1 g of toothpaste contains contains 2.8 mg fluoride (as sodium fluoride), corresponding to 2800 ppm fluoride, sodium fluoride 0.619 % w/w. This site uses cookies. Morningside House, Unit C Harcourt Way, Meridian Business Park, Leicester, LE19 1WP. 1-4 Sodium Fluoride 5000 ppm Sensitive 1.1% sodium fluoride toothpaste with 5% potassium nitrate in a squeeze-tube is easily applied onto a toothbrush. Deduce the maximum mass of sodium fluoride, in mg, that a 75.0 kg person could swallow without reaching the toxic concentration. Fluoride ions are excreted mainly in urine, but small amounts may also be excreted in faeces and sweat. It is not known in which form. When carrying out overall calculations of the recommended fluoride ion intake, which is 0.05 mg/ Kg body weight per day from all sources, not exceeding 1 mg per day, allowance must be made for possible ingestion of toothpaste (each 75 ml tube of Fluoride 2800 ppm Toothpaste contains 280 mg of fluoride ions). When suggestions are available use up and down arrows to review and ENTER to select. Fluoride in toothpaste is usually in the form of sodium fluoride (NaF) or sodium monofluorophosphate (MFP). Fluoride toothpastes are more effective at preventing tooth decay at higher fluoride concentrations. Use your answer to Question (b) to deduce the mass of toothpaste, in kg, that a 75.0 kg Morningside House, Unit C Harcourt Way, Meridian Business Park, Leicester, LE19 1WP. 51g. Patients or carers should be given advice on how to administer sodium fluoride toothpaste. Prescription strength toothpaste contains sodium fluoride at a concentration of over 1500ppm up to 5,000ppm. • The active substance is fluoride, as sodium fluoride. Ingested fluride is converted to hydrofluoric acid. Four years later, the first fluoride toothpaste, known as Crest, was released. Fluoride 2800 ppm toothpaste,Elastoplast fabric plastersFluoride 2800 ppm toothpaste,Desogestrel pill reviews This site uses cookies. Fluoride 2800 ppm Toothpaste has no or negligible influence on the ability to drive and use machines. I had an anti-fluoride patient the other day that was saying he read somewhere that a pea-sized amount of toothpaste contains the same amount of fluoride in 1 liter of tap water (1 ppm). The investigation into the effect of fluoride on dental health began in 1909 with Dr. Frederick McKay. Fluoride 2800 ppm Toothpaste is indicated in adolescents, and children aged 10 years and over. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system, the Yellow card scheme at: www.mhra.gov.uk/yellowcard. To view the changes to a medicine you must sign up and log in. Fluoride 2800 ppm Toothpaste is contraindicated in children aged under 10 years, see section 4.3. Reporting suspected adverse reactions after authorisation of the medicinal product is important. It is written for patients and gives information about taking or using a medicine. Continue typing to refine. When suggestions are available use up and down arrows to review and ENTER to select. A range of toothpastes are available containing different levels of fluoride. May be prescribed as Sodium Fluoride Toothpaste 0.619%. Duraphat ® 2800 ppm Fluoride Toothpaste is used for the prevention and treatment of dental caries (tooth decay). Sorbitol solution (non-crystallising), E420, Mint flavour (947093 Optamint Spearmint) containing menthol, propylene glycol, spearmint oil, carvone, anethol, ethyl maltol, vanillin. Patients with rare hereditary problems of fructose intolerance should not take this medicine. Available size: 75ml The amount of fluoride in the toothpaste can be found on the side of the tube and is measured in parts per million (ppm). Excipient (s) with known effect: Sorbitol solution (non-crystallising) Propylene glycol. Such intoxication appears in the form of digestive problems: vomiting, diarrhoea, abdominal pain. High concentration fluoride toothpastes are a relatively recent innovation and come in two strengths. Active ingredient: Sodium Fluoride 0.619 %w/w (2800 ppm F-). Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. For the full list of excipients, see section 6.1. MPL15303. Tube. 4.4 out of 5 stars 5,895. Fluoride ions are distributed to teeth and bones, and are not bound to plasma proteins. It is a generic version of Colgate Duraphat toothpaste. Used for prevention of dental caries especially if you are more prone due to smoking, drinking and eating lots of sugary snacks. What the scientists found (and future research confirmed) was that fluoride help… Several 1.1% sodium fluoride toothpaste formulations are currently available in the market and are primarily dispensed through pharmacies. Therefore, a pea-sized amount of toothpaste containing 1000 to 1100 ppm fluoride would have approximately 0.25 mg of fluoride. 1 g of toothpaste contains contains 2.8 mg fluoride (as sodium fluoride), corresponding to 2800 ppm fluoride, sodium fluoride 0.619 % w/w. 3M™ Clinpro™ 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste A 20 per cent reduction in DMFS increment was seen after one year of use. 75ml. Rare (> 1 / 10,000, < 1 / 1,000): hypersensitivity reactions. To email a medicine you must sign up and log in. Qualitative and quantitative composition, 4.2 Posology and method of administration, 4.4 Special warnings and precautions for use, 4.5 Interaction with other medicinal products and other forms of interaction, 4.7 Effects on ability to drive and use machines, 6.6 Special precautions for disposal and other handling, 9. Morningside 5000 Toothpaste contains 5000ppm of Sodium fluoride, around four times as much than in normal toothpaste. Dental practitioners' formulary. 120-3231. Fluoride toothpaste. The dental enamel will take on a stained or speckled appearance once a fluoride dosage in excess of 1.5 mg per day is absorbed daily over several months or years, depending on the extent of overdose. The total amount of fluoride in a 75 ml tube of Fluoride 2800 ppm Toothpaste is about 620 mg which equates to 280 mg fluoride. This toothpaste contains fluoride as sodium salt, which belongs to a group of medicines called caries preventing agents. The terminal half life is in the range 2 – 9 hours. Mouthwashes may be prescribed as Sodium Fluoride Mouthwash 0.05% or Sodium Fluoride Mouthwash 2%. Brush carefully and thoroughly, for one minute, morning and evening: - Apply a 1 cm ribbon of toothpaste onto the toothbrush for each brushing, - Brush teeth vertically, from the gum to the tip of the teeth, - Careful brushing takes approximately one minute, - For best results do not drink or rinse for 30 minutes. Continue typing to refine. By continuing to browse the site you are agreeing to our policy on the use of cookies. If needed for therapeutic reasons, toothpastes containing more than 1,500 ppm F (e.g., 2,800 ppm F) are available but may be obtained only with a prescription. Prescription only. Colgate Duraphat ® 2800 ppm Fluoride Toothpaste – Name of the medicinal product: Duraphat ® 2800 ppm Fluoride Toothpaste. An increased number of potential fluoride sources may lead to fluorosis. Dental information Fluoride mouthwash, oral drops, tablets and toothpaste are prescribable on form FP10D (GP14 in Scotland, WP10D in Wales. Use your answer to Question 02.2 to deduce the mass of toothpaste, in kg, that a 1 g of toothpaste contains contains 2.8 mg fluoride (as sodium fluoride), corresponding to 2800 ppm fluoride, sodium fluoride 0.619 % w/w. Read more about the prescription drug SODIUM FLUORIDE 1.1% TOOTHPASTE - … Fluoride 2800 ppm Toothpaste. This high fluoride toothpaste that can help to prevent and reverse the early stages of tooth decay. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION. Start typing to retrieve search suggestions. Fluoride 2800 ppm Toothpaste - Patient Information Leaflet (PIL) by Morningside Healthcare Ltd This product is not intended to be swallowed and therefore only minimal systemic exposure is expected. Fluoride 2800 ppm Toothpaste can be used during pregnancy and lactation. Treatment: where a substantial quantity of the medicinal product is ingested accidentally, the patient will need to undergo gastric lavage immediately, or vomiting will need to be induceed; calcium needs tyo be taken (large amount of milk), and the patient will require to be kept under medical observation for several hours. Studies in animals have shown reproductive toxicity of sodium fluoride only when administered at very high levels (see section 5.3). Continue, 2. Deduce the maximum mass of sodium fluoride, in mg, that a 75.0 kg person could swallow without reaching the toxic concentration. Propylene glycol may cause skin irritation. This will be accompanied by increased enamel fragility in severe forms. The volume of distribution is 1 L / Kg. This is huge for something you only have to spend about 4 minutes doing! Officials in Grand Rapids, MI were the first to add fluoride to the city’s drinking water in 1945. Use by children aged under ten years, see section 4.2. However, the following information has been included in case any toothpaste is accidentally ingested during treatment. A 1000 ppm fluoride toothpaste reduces cavities by approximately 23% while a toothpaste in the range of 2400-2800 ppm reduces cavities by about 36%. This product should not be used by children aged under ten years, see sections 4.2 and 4.3. It was only in 1952 that scientists with the Proctor & Gamble corporation began conducting clinical trials of a fluoride-enhanced toothpaste involving 1,500 children and 100 adults. Excipient(s) with known effect: Sorbitol solution (non-crystallising) Propylene glycol. By continuing to browse the site you are agreeing to our policy on the use of cookies. A dental caries preventive; for once daily self-applied topical use. Sodium Fluoride 2800 ppm Toothpaste. Consumer information about the medication SODIUM FLUORIDE 1.1% TOOTHPASTE - DENTAL, includes side effects, drug interactions, recommended dosages, and storage information. This translates into 1 mg of fluoride in a 1-inch (1 g) strip of paste. Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, toxicity to reproduction and development. Ingested fluride is converted to hydrofluoric acid.

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